Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly

摘要

A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.