A method to quantify and map iron deposits in the brain with diffusion-weighted magnetic resonance imaging (MRI) is based on the differential sensitivity of mono-polar (MPG) gradient pulse diffusion sequences and bipolar (BPG) sequences on the local magnetic field gradients induced by iron deposits and their cross-term with the diffusion-encoding gradients. The method comprises the steps of acquiring (12, 14) first MRI images and second MRI of a Region Of Interest by using MPG and BPG sequences, providing (16) an attenuation model of the diffusion MRI attenuated signal representative of the observed tissue, estimating (18, 20) a first apparent diffusion coefficient ADCMPG and a second apparent diffusion coefficient ADCBPG by fitting the MRI images with the attenuation model, calculating (22) a an iron induced local gradient factor ξFe as (Formula I) (I), and determining (24) the concentration [Fe] and/or the amount of iron stored in the local zone of the tissue from the calculated iron induced local gradient factor ξFe. An apparatus is configured for implementing such a method.
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机译:一种基于扩散加权磁共振成像(MRI)定量和映射大脑中铁沉积物的方法是基于单极性(MPG)梯度脉冲扩散序列和双极性(BPG)序列在局部磁场梯度上的差分灵敏度铁沉积物引起的磁感应强度及其与扩散编码梯度的交叉项。该方法包括以下步骤:使用MPG和BPG序列获取( 12,14 B>)感兴趣区域的第一张MRI图像和第二张MRI,提供( 16 B>)衰减代表观察组织的扩散MRI衰减信号的模型,通过将MRI图像与衰减模型拟合,估算( 18,20 B>)第一表观扩散系数ADCMPG和第二表观扩散系数ADCBPG, ( 22 B>)a铁诱导的局部梯度因子ξ Fe Sub>为(公式I)(I),并确定( 24 B>)浓度[ [Fe]和/或根据计算出的铁诱导的局部梯度因子ξ Fe Sub>从组织的局部区域存储的铁量。装置被配置用于实现这种方法。
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