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CHIMERIC REPORTER WEST NILE/DENGUE VIRUSES AND THEIR USE
CHIMERIC REPORTER WEST NILE/DENGUE VIRUSES AND THEIR USE
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机译:嵌合报告者西尼罗河/登革热病毒及其使用
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摘要
Chimeric flaviviruses engineered to contain a reporter gene and chimeric nucleic acid molecules encoding the chimeric flaviviruses are described. The chimeric flaviviruses further include genomic non-coding regions, non-structural proteins, and at least a portion of a capsid (C) protein from West Nile virus (WNV), and premembrane (prM) and envelope (E) proteins from dengue virus (DENV). Diagnostic assays that utilize chimeric West Nile/dengue viruses are further described.
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