A lettuce cultivar, designated VX 12 MB, is disclosed. The invention relates to the seeds, plants and plant parts of lettuce cultivar VX 12 MB and to methods for producing a lettuce plant by crossing the cultivar VX 12 MB with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar VX 12 MB, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar VX 12 MB and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar VX 12 MB with another lettuce cultivar.
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