首页>
外国专利>
Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy
Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy
展开▼
机译:可生物降解的热响应注射水凝胶用于治疗缺血性心肌病
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
展开▼