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Diagnosis-treatment Integrated nano-probe for 19F-MR/fluorescence multi-mode molecular imaging and drug-loading and preparation method and application of nano-probe
Diagnosis-treatment Integrated nano-probe for 19F-MR/fluorescence multi-mode molecular imaging and drug-loading and preparation method and application of nano-probe
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机译:用于19F-MR /荧光多模分子成像和载药的诊疗一体化纳米探针及其制备方法和应用
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摘要
The present invention provides a 19F-MR/fluorescence multi-mode molecular imaging and drug loading diagnosis-treatment integrated nanoprobe, and a preparation method and an application. The nano-probe is a nanoparticle formed by coating a mixture of a surfactant containing a molecular targeting treatment drug and a fluorescent dye with a Perfluorocarbon (PFC) carrier; and by uniformly dispersing a mixed solution into water and glycerol, processing ultrasonically, removing a component which is not effectively coated, and purifying, the drug-loading nanoparticle capable of being used for 19 F-MR imaging may be prepared. The nano-probe may implement in-vivo 19F-MR molecular imaging; a carried molecular targeting treatment drug can implement targeted binding and targeted treatment; and by virtue of a characteristic that PFC in a nucleus may carry and release oxygen massively, an anaerobious microenvironment in the tumor is improved, a chemosensitization effect is achieved, and thus the diagnosis-treatment integration of the tumor is implemented finally.
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