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GENETICALLY MODIFIED MESENCHYMAL STEM CELLS EXPRESSING AN IMMUNE RESPONSE-STIMULATING CYTOKINE TO ATTRACT AND/OR ACTIVATE IMMUNE CELLS
GENETICALLY MODIFIED MESENCHYMAL STEM CELLS EXPRESSING AN IMMUNE RESPONSE-STIMULATING CYTOKINE TO ATTRACT AND/OR ACTIVATE IMMUNE CELLS
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机译:遗传修饰的间充质干细胞表达免疫应答刺激性细胞因子吸引和/或激活免疫细胞
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摘要
A method of treating a tumor in a subject including administering a genetically modified mesenchymal stem cell (MSC), wherein the MSC includes one or more exogenous nucleic acid molecule(s), wherein the one or more exogenous nucleic acid molecule(s) includes one or more regions encoding two or more immune response-stimulating cytokines operably linked to one or more promoters or promoter/enhancer combinations, wherein the two or more immune response-stimulating cytokines include at least IL-7, and at least one of IL-12 or IL-21.
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