MORPHIC FORMS OF G1T38 AND METHODS OF MANUFACTURE THEREOF

摘要

This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of 2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one for advantageous therapeutic pharmaceutical efficacy and dosage form stability.