Mass spectrometric method and MALDI-TOF mass spectrometer

摘要

A number of standard methods exist for normalizing MALDI-TOF data, but they are not able to compensate adequately for the observed technical variability. The invention creates an improved normalization method for MALDI-TOF mass spectrometry data. This is achieved by an intensity profile normalization, where, by way of example,;1) Firstly, an intensity profile is formed for each individual spectrum, and this intensity profile describes the statistical distribution of the intensity values within different mass ranges;;2) Then an average reference profile is formed for an ensemble of spectra;;3) Finally, the individual spectra are transformed in such a way that their intensity profiles correspond to the reference profile.