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AFFINITY-TAGGED PHOTOSWITCHES AND METHODS OF USE THEREOF
AFFINITY-TAGGED PHOTOSWITCHES AND METHODS OF USE THEREOF
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机译:带有亲和力的光电开关及其使用方法
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摘要
The present disclosure provides a conjugate comprising: a) an affinity agent that specifically binds a target ligand-binding polypeptide; and b) a photoisomerizable regulator comprising: i) a photoisomerizable moiety; and ii) a ligand that binds to the target ligand-binding polypeptide. The present disclosure provides cells comprising a conjugate of the present disclosure. The present disclosure provides methods of using a conjugate of the present disclosure to modulate activity of a target polypeptide, and to modulate activity of a target cell or cell population.
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