METHODS FOR DIAGNOSING INFLAMMATORY PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

摘要

Provided herein are methods for diagnosing the COPD inflammatory phenotype of an individual, and methods for selecting individuals with COPD for treatment based on their COPD inflammatory phenotype. In particular embodiments the methods comprise determining the level of expression of one or more genes selected from CLC, CPA3, DNASE1L3, IL1B, ALPL and CXCR2, or determining the expression profile CLC, CPA3, DNASE1L3, IL1B, ALPL and CXCR2, in one or more biological samples from an individual, wherein the expression levels or expression profile are indicative of the COPD inflammatory phenotype.