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Cytomegalovirus Vectors Eliciting T Cells Restricted By Major Histocompatibility Complex E Molecules
Cytomegalovirus Vectors Eliciting T Cells Restricted By Major Histocompatibility Complex E Molecules
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机译:巨细胞病毒载体消除主要组织相容性复合体E分子限制的T细胞
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摘要
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
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