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AAV Split Cas9 Genome Editing and Transcriptional Regulation
AAV Split Cas9 Genome Editing and Transcriptional Regulation
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机译:AAV拆分Cas9基因组编辑和转录调控
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摘要
The invention provides methods of altering a target nucleic acid in a cell using the AAV split Cas9 platform. The methods comprise providing the cell an enzymatically active Cas9 and optionally a transcriptional regulator fused thereto and guide RNA having different spacer sequence lengths wherein the guide RNA directs the enzymatically active Cas9 and optionally a transcriptional regulator fused thereto to either cleave a target nucleic acid or regulate expression of a target nucleic acid.
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