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Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy
Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy
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机译:靶向Mcl-1以增强DNA复制对癌症治疗的压力敏感性
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摘要
This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.
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