PALLADIUM (II)-CATALYZED gammaC(SP³)-H ALKYNYLATION OF AMINE2

摘要

The present invention relates to a Palladium (II)-catalyzed C(sp³)—H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.