MEDICAL APPLICATION OF COMPOSITION OF FRUCTOSE-1,6-BISPHOSPHATE AND BLOOD CONCENTRATION STABILIZER THEREOF

摘要

Application of a composition of FBP and a blood concentration stabilizer thereof in manufacturing medicaments for preventing and treating metabolic diseases and metabolic dysfunction related diseases. The FBP may also be a pharmaceutically acceptable salt or hydrate of prototype thereof, a prodrug thereof, or a derivative thereof. The blood concentration stabilizer refers to a medicament or substance for treating diabetes capable of slowing down rapid in vivo degradation of FBP in a pharmaceutical preparation. The composition can cause a higher FBP blood concentration peak value and a more stable blood concentration, and can reduce an FBP dosage and thus can reduce the toxicity resulted from a large amount of inorganic phosphorus entering systemic circulation after degradation of a large dosage of FBP.