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AGENT THAT INCREASES THE EXPRESSION OF THE OPIOID KAPPA 1 FOR THE TREATMENT OF CANCER
AGENT THAT INCREASES THE EXPRESSION OF THE OPIOID KAPPA 1 FOR THE TREATMENT OF CANCER
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机译:增加阿片类药物kappa 1的表达以治疗癌症的药物
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摘要
It has been found by the present inventors that agents that boost the expression of the opioid receptor kappa 1 (OPRK1) can enhance the cytotoxicity of chemotherapeutic agents in multiple cancer cell lines. Furthermore, the effect is dose dependent, where the greater the induced expression of OPRK1, the greater the cytotoxicity of the chemotherapeutic agent. The increase in overall cytotoxicity is independent of the cytotoxicity of the agent that increases the expression of OPRK1, which itself has no or minimal cytotoxic effect.
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