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Methotrexate adjuvants to reduce toxicity and methods for using the same
Methotrexate adjuvants to reduce toxicity and methods for using the same
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机译:降低毒性的甲氨蝶呤佐剂及其使用方法
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摘要
Methods are provided for using methotrexate (MTX) active agents in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of an MTX active agent in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2′-anhydropyrimidine, a derivative thereof or a uridine phosphorylase inhibitor. Also provided are compositions and kits that find use in practicing embodiments of the invention. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.
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