ARTIFICIAL ANTIGEN PRESENTING CELLS INCLUDING HLA-E AND HLA-G MOLECULES AND METHODS OF USE

摘要

The present disclosure relates to artificial antigen presenting cells (aAPCs), in particular engineered erythroid cells and enucleated cells (e.g., enucleated erythroid cells and platelets), that are engineered to include exogenous-antigen presenting polypeptides comprising either HLA-E or HLA-G polypeptides, which may be used to activate or suppress certain immune cells.