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IN VITRO PRODUCTION OF RED BLOOD CELLS WITH PROTEINS COMPRISING SORTASE RECOGNITION MOTIFS
IN VITRO PRODUCTION OF RED BLOOD CELLS WITH PROTEINS COMPRISING SORTASE RECOGNITION MOTIFS
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机译:含山梨糖醇酶识别蛋白的蛋白质在体外生产红色血液细胞
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摘要
Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
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