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METHODS FOR DETECTING MUTATION LOAD FROM A TUMOR SAMPLE
METHODS FOR DETECTING MUTATION LOAD FROM A TUMOR SAMPLE
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机译:从肿瘤样本中检测变异负载的方法
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摘要
A targeted panel with low sample input requirements from a tumor only sample may be processed to estimate mutation load in a tumor sample. The method may include: detecting variants in nucleic acid sequence reads corresponding to targeted locations in the tumor sample genome; annotating detected variants with an annotation information from a population database; filtering the detected variants, wherein the filtering retains the somatic variants and removes germline variants; calculating an initial TMB; and applying a calibration to the initial TMB level to produce a final TMB level for the mutation load of the tumor sample genome. The filtering may also include retaining nonsynonymous SNVs and indels for the analysis.
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