polypeptide with asparaginase activity, polynucleotide, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating neoplasms, and, use of a polypeptide

摘要

The present invention relates to modified E. coli L-asparaginase in order to decrease its interaction with different amino acids other than asparagine, more preferably, glutamine. Also described herein are polynucleotides encoding the polypeptides of the invention, expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the polypeptide of the invention in the manufacture of a cancer prevention or treatment drug and methods for producing the polypeptide of the invention and to prevent or treat neoplasms.