human protein peptides from heat stress, pharmaceutical composition, and use of peptide and pharmaceutical composition

摘要

human heat stress protein peptides of 60 kda that constitute epitopes for t cells, as well as peptides derived from them, which are modified at the sites of contact with the mhc molecule, useful to induce peripheral tolerance mechanisms, in particular anergy-inducing mechanisms or mediated by regulatory t cell clones in patients with rheumatoid arthritis. the invention also relates to pharmaceutical compositions comprising such peptides for the treatment of rheumatoid arthritis.