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stable liquid composition comprising botulinum toxin and method for stabilizing a botulinum toxin
stable liquid composition comprising botulinum toxin and method for stabilizing a botulinum toxin
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机译:稳定的包含肉毒杆菌毒素的液体组合物和稳定肉毒杆菌毒素的方法
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摘要
the present invention relates to a stable liquid composition comprising botulinum toxin as an active ingredient, ready for use without the need for a reconstitution process and, in particular, a composition capable of preventing the aggregation of botulinum toxin, even when in low concentration, to exhibit high stability, to effectively prevent adsorption, etc., to a container, to maintain constant activity of the toxin for each batch or for each liquid bottle. specifically refers to a liquid composition comprising (i) a botulinum toxin as an active ingredient, (ii) 1-alanine or methylcellulose, (iii) a nonionic surfactant and (iv) a buffer and, optionally, an isotonic agent.
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