method of treating a seizure disorder in a patient who needs it and vector

摘要

methods of treating a seizure disorder in a patient who needs it and vector methods and compositions are provided to treat a seizure disorder which include administering to the patient a vector encoding a modified receptor for the release of the modified receptor to the target location, the receptor modified being modified to be activated by a synthetic ligand, in which the modified receptor inhibits neuronal firing when activated; and administering the synthetic ligand to the patient. methods and compositions are also provided for treating a seizure disorder in a patient who needs it by administering to the patient a vector encoding a modified receptor for the release of the modified receptor to the target location, the modified receptor being modified to be activated by a ligand synthetic, in which the modified receptor increases neuronal firing when activated; and administering the synthetic ligand to the patient. the methods are used to improve or relieve one or more symptoms of a seizure disorder.