oncolytic viruses for sensitizing tumor cells to death by natural killer cells

摘要

the present invention relates to engineered oncolytic viruses, related fusion proteins and polynucleotides that encode them, and methods for treating cancer using the engineered viruses. in one aspect, manipulated oncolytic viruses are disclosed herein, wherein the oncolytic virus expresses one or more immune cell targeting ligands attached to the exogenous membrane comprising an uncleaved signal anchor.