method for controlling the level of a polypeptide sequence, chimeric antigen receptor, fusion protein, isolated polynucleotide, expression vector, cell, pharmaceutical composition, and method for engineering an immunomodulatory cell.

摘要

the invention relates to a method for controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein that comprises a minimal structural degron motif. in particular, the polypeptide sequence comprises a chimeric antigen receptor so the present invention is useful in cell and gene therapy methods where the activity of the chimeric antigen receptor needs to be controlled.