polypeptide, nucleic acid, vector, collection of one or more expression vectors, composition comprising a vaccine and vaccination kit

摘要

the present invention provides a polypeptide comprising at least four different tumor-specific neoantigens fused to at least one t cell enhancing amino acid sequence, a nucleic acid sequence encoding that polypeptide, a vector comprising that nucleic acid sequence and a collection of vectors comprising such vectors. in addition, compositions of matter are provided which comprise in mixture or separately a vaccine comprising the polypeptide, the nucleic acid sequence, the vector or the vector collection of the invention and at least one modulator of a checkpoint molecule or another type of immunomodulator for use in the treatment of cancer.