methods to reduce one or more symptoms of gastroesophageal reflux disease, to treat a disease and to treat / prevent signs and / or symptoms associated with bile acid reflux, gastroretective oral dosage form, and pharmaceutical composition.

摘要

methods and formulations to reduce one or more symptoms of gastroesophageal reflux disease (gerd) in a human patient with symptomatic gerd not completely responsive to proton pump inhibitors (ppis). the patient is administered a therapeutically effective amount of an enteric coated gastroretective oral dosage form in the form of a bile acid scavenger tablet dispersed in a polymeric matrix consisting essentially of poly (alkylene) oxide and one or more fillers or compression agent, so that the patient experiences a clinically significant reduction in one or more symptoms of gerd.