methods to elicit a mucosal immune response to group a streptococcal bacteria and to induce mucosal immunity, method of treatment or prevention of an infection and composition

摘要

a modified p145 peptide with increased mucosal immunogenicity for use in inducing a mucosal immune response to group a streptococcal bacteria in a mammal such as a human. intramuscular administration of the modified p145 peptide can be particularly effective. a peptide or s2 variant can be co-administered with the modified p145 peptide to improve the immune response.