ANTI-IGF-IR ANTIBODIES, THEIR PRODUCTION METHOD AND ITS USES, MURINO HIBRIDOMA, ISOLATED NUCLEIC ACID, VECTOR, COMPOSITION, KIT OR ASSEMBLY, AND IN VITRO DIAGNOSTIC METHOD OF DISEASES INDUCED BY AN EXPRESSION OF EXPRESSION OR REPRESSION

摘要

"anti-igf-ir antibodies and their applications". the present invention relates to new antibodies capable of specifically binding to the human growth factor i receptor similar to the insulin igf-ir and / or capable of specifically inhibiting the tyrosine kinase activity of that igf-ir receptor, notably monocytes of murine origin , chimeric and humanized, as well as the amino acid and nucleic sequences encoding for these antibodies. the invention also encompasses the use of these antibodies as a medicine for the prophylactic and / or therapeutic treatment of cancers, as well as in processes or diagnostics necessary for diseases linked to the overexpression of the igf-ir receptor. the invention finally comprises products and / or compositions that comprise these antibodies in association with anti-egfr antibodies and / or compounds and / or anti-cancer agents or conjugated with toxins and their use for the prevention and / or treatment of certain cancers.