synergistic immunogenic compositions based on protein antigens combined with pertussis cell antigen and inactivated toxins

摘要

SYNERGIC IMMUNOGENIC COMPOSITIONS BASED ON PROTEIN ANTIGENS COMBINED WITH PERTUSSIS CELL ANTIGEN AND INACTIVED TOXINS. The present invention relates to synergistic immunogenic compositions for the prevention of pertussis and infections caused by Streptococcus pneumoniae. In addition, the compositions of the present invention can offer protection against infections caused by other pathogens through the synergistic combination of antigens thereof. In particular, the present invention provides synergistic immunogenic compositions that comprise at least one inactivated .Borcletella pertussi.s cell antigen and at least one protein antigen comprising one or more Streptococcus pneumoniae surface A (PspA) proteins or fragments thereof. The present invention further provides synergistic immunogenic compositions comprising at least one inactivated Bordetella pertus.sis cell antigen, at least one protein antigen comprising one or more Streptococcus pneumoniae surface A (PspA) proteins or fragments thereof and one or more diphtheria and / or tetanus toxins. The present invention also relates to the use of one or more synergistic immunogenic compositions of the present invention in the manufacture of combined vaccines for prevention of whooping cough, tetanus, diphtheria and / or infections caused by Streptococcus pneumoniae. The present invention also relates to the use of the compositions of the present (...).