ISOQUINOLIN-1 (2H) -ONE DERIVATIVES AS PARP-I INHIBITORS

摘要

isoquinolin-1 (2h) -one derivatives as parp-i inhibitors the invention relates to substituted isoquinolin-1 (2h) -one derivatives that selectively inhibit the polypolymer activity (adp-ribose) parp-1 over In addition to poly polymerase (adp-ribose) parp-2, the compounds of the invention are therefore useful in the treatment of diseases such as cancer, cardiovascular diseases, damage to the nervous system and various forms of inflammation. the invention also relates to methods for preparing such compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases using pharmaceutical compositions comprising these compounds. a screening method for the identification of compounds capable of binding to various parp proteins, thus the evidence used in such a method, are also objects of the invention.