Animals other than humans are supplied,e.g. mammals,e.g. mice or rats,comprising a heavy chain genetic site of immunoglobulin comprising a rearranged human nucleotide sequence of a variable range of heavy chains of immunoglobulinCommunity. The rearranged human nucleotide sequence of a variable range of heavy chain immunoglobulin may be functionally linked to a stable nucleotide sequence. heavy areaor a light chain. Genetically modified animals other than humans comprising a genetic site of a light chain of immunoglobulin comprising one or morebut less than the natural type number,human genetic parts of a variable region of the light chain of immunoglobulin,which can be functionally linked to a nuclear sequence of a fixed area of a light chain. Methods for taking nucleoxy are also providedsequences encoding variable areas of the light chain of immunoglobulin with the ability to bind an antigen in the absence of a heavy chain.
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