MODELS OF ANIMALS SPECIFIC TO THE HUMAN DEATH PRODUCER AND USE OF ANIMAL ANIMALS

摘要

Antibody molecules containing at least one CDR derived from mouse monoclonal antibodies shall be described,specializing in human TNF. It also describes a CDR grafted antibody where at least one of the CDRs is a hybrid CDR. Additional DNA sequences encoding the antibody chains are described,institutions,transformed host cells and uses of antibodies to treat diseases mediated by TNF.