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METHOD FOR PREPARING (2Z, 5Z) -5- (3-CHLOR-4 - ((R) -2,3-DIHYDROXYPROPOXY) BENZYLIDE) -2- (PROPYLIMINO) -3- (O-TOLYL) THIAZOLIDIN-4- ON AND INTERMEDIATE PRODUCTS USED IN THE PROCEDURE
METHOD FOR PREPARING (2Z, 5Z) -5- (3-CHLOR-4 - ((R) -2,3-DIHYDROXYPROPOXY) BENZYLIDE) -2- (PROPYLIMINO) -3- (O-TOLYL) THIAZOLIDIN-4- ON AND INTERMEDIATE PRODUCTS USED IN THE PROCEDURE
The present invention relates to a new process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and to the new intermediate (R)-3-chloro-4-(2,3-dihydroxypropoxy)-benzaldehyde used in this process. (2Z,5Z)-5-(3-Chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one is described in WO 2005/054215 to act as an immunosuppressive agent. The present invention further also relates to a new process for the preparation of (R)-3-chloro-4-(2,3-dihydroxypropoxy)-benzaldehyde.
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机译：制备（2Z，5Z）-5-（3-氯-4-（（R）-2,3-二羟基丙氧基）亚苄基）-2-（丙基亚氨基）-3-（邻甲苯基）噻唑烷丁-4-酮和用于该方法的新中间体（R）-3-氯-4-（2,3-二羟基丙氧基）-苯甲醛。 （2Z，5Z）-5-（3-氯-4-（（R）-2，3-二羟基丙氧基）亚苄基）-2-（丙基亚氨基）-3-（邻甲苯基）噻唑烷-4--4- WO 2005/054215充当免疫抑制剂。本发明还涉及制备（R）-3-氯-4-（2，3-二羟基丙氧基）-苯甲醛的新方法。
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