SUBSTITUTED AROMATIC COMPOUNDS FOR TREATMENT OF LUNGFibrosis, Liver Fibrosis, Skin Fibrosis and Heart Fibrosis

摘要

The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)(CH2)nCH3 or CH(OH)(CH2)nCH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)C(O)OH, 5) CF2C(O)OH, or 6) C(O)C(O)OH.