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TROPHOBLAST GLYCOPROTEIN (5T4, TPBG) -Specific Chimeric Antigen Receptors for Cancer Therapy
TROPHOBLAST GLYCOPROTEIN (5T4, TPBG) -Specific Chimeric Antigen Receptors for Cancer Therapy
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机译:滋养层糖蛋白(5T4,TPBG)-癌症治疗的特异性嵌合抗原受体
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摘要
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a 5T4 monoclonal antibody, conferring specific immunity against 5T4 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia, and for solid tumors such as colon, stomach, and ovarian tumors.
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