METHODS FOR TREATING DISEASES AND DISORDERS MEDIATED BY KOMPLEMENT

摘要

The present disclosure provides methods of treating a complement-mediated disease or disorder in a subject and methods of inhibiting the activation of the complement component C4 in a subject in need thereof. The methods include administering an anti-C1s antibody to a subject. The methods also include administering a fixed dose of anti-C1s antibody, for example 5.5, 6.5, or 7.5 g. The methods also include administering an effective dose of an anti-C1s antibody to a subject to achieve a minimum serum level of anti-C1s - antibodies for therapeutic effect.