2-(4-isobutylphenyl) propionic acid drug intermediates synthesis method

摘要

The present invention discloses 2-(4-isobutylphenyl) propionic acid drug intermediates synthesis method, comprises the following steps: 2-(4-isobutylphenyl) propanol and biphenyl solution are added to the reaction vessel, the temperature of the solution is raised, the aqueous solution is added, potassium peroxydisulfate is added, continues to react; tetrabutoxy zirconium powder is added in batches, then potassium sulfate solution is added, raises the temperature, controls the stirring speed, reacts, lowers the temperature, potassium chloride solution is added, the solution layers, separate the oil layer, adjusts the pHwith the formic acid solution, washed with hexyl ether solution, recrystallizes from 2-ethyl butanol solution, dehydrated with dehydration, gets the finished product 2-(4-isobutyl phenyl) propionic acid. Figure 1