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Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing dicarboxylic acid bisamide derivatives

机译:二羧酸双酰胺衍生物,其用途,基于其的药物组合物和生产二羧酸双酰胺衍生物的方法

摘要

The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which are able to form complexes with or chelate metal ions. The invention also relates to the use of said compounds as an agent for the prevention and/or treatment of cardiovascular, viral, cancer, neurodegenerative and inflammatory diseases, diabetes, age-related diseases, diseases caused by microbial toxins, alcoholism and alcoholic cirrhosis, anaemia, porphyria cutanea tarda, and transition metal salt poisoning. The present invention also relates to novel methods for preparing dicarboxylic acid bisamide derivatives of general formula I.
机译:本发明涉及新颖的生物活性化合物,特别是通式I的二羧酸双酰胺衍生物:或其药学上可接受的盐,它们能够与金属离子形成络合物或螯合金属离子。本发明还涉及所述化合物作为预防和/或治疗心血管,病毒,癌症,神经退行性和炎性疾病,糖尿病,与年龄有关的疾病,由微生物毒素引起的疾病,酒精中毒和酒精性肝硬化的药物的用途,贫血,皮肤卟啉病,过渡金属盐中毒。本发明还涉及制备通式I的二羧酸双酰胺衍生物的新方法。

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