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New T cell phone receivers, and immunotherapy using these phones

机译:新的T手机接收器,以及使用这些手机的免疫疗法

摘要

The invention relates to the construction of an anti-virus agent identifying an antigen of a tumor related antigen (TAA).In particular, TAA symmetrical as "serine cucumber inhibitor 2 of Kazakhstan" (spink2). In particular, the invention provides innovative molecules based on new t (TCR) cell receptors, which are selective and specific for antigens of the invention expressed against tumors. TCR in the invention, as well as fragments produced by binding with spink2 antigen, are used for diagnosis, treatment and prevention of spiral tumor diseases. In addition, nucleic acids are provided for the preparation of anti-virus components for inventions of vehicles including these nucleic acids,Reset cells represent known antique manufacturers and pharmacological components, including compounds of invention.
机译:本发明涉及鉴定肿瘤相关抗原(TAA)的抗原的抗病毒剂的构建。特别地,对称地作为“哈萨克斯坦的丝氨酸黄瓜抑制剂2”(spink2)的TAA。特别地,本发明提供了基于新的t(TCR)细胞受体的创新分子,其对本发明针对肿瘤表达的抗原具有选择性和特异性。本发明中的TCR以及通过与spink2抗原结合而产生的片段被用于诊断,治疗和预防螺旋肿瘤疾病。另外,提供了用于制备用于本发明的载体的抗病毒组分的核酸,包括这些核酸。重置细胞代表已知的古董制造商和药理学组分,包括本发明的化合物。

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