Polypeptides against viral signaling in tumor cells

摘要

Polyurethane designated as low density lipoprotein (LRP5) 5 proteome;It consists of a single variable domain of immunoglobulin (ISVD) selected from the following groups: (I) an ISVD consisting of the following complementary determining region sequences: CDR1: tyvmg (SEQ ID No.1),CDR2：Aiwsggstyyadskg（SEQ ID No:2），CDR3:Srgtstpsrastravsrydy（SEQ ID No:3），(II) an ISVD, including sequence: CDR1: ryava (SEQ ID No: 4);CDR2：AITWSGridyadskg（SEQ ID No:5），CDR3:Drrprstgrgsgtgspstydy（SEQ ID No:6）；（3） An ISVD includes CDR1: igamg (SEQ ID No.7);CDR2：Avssggstyvdsvkg（SEQ id No:8），CDR3: etgpypkrdy (SEQ ID No.9) and (IV) UN ISVD include: CDR1: inamg (SEQ ID No.10)CDR2：Avssggstyvdsvkg（SEQ id No:8），CDR3：ETGPYGPPKRDY（SEQ ID No：9）. This polyurethane inhibits the pathway of sensitization Wnt1 / Wnt3a, and is useful in the treatment of breast cancer and lung cancer. He also mentioned a nucleic acid molecule that encodes polypeptides, an expression vector, a hollow cell, a pharmacological component, including polypeptides, a production method, and a treatment method.