PROCESS FOR OBTAINING A NEW CLASS OF ANTHRACENE-IMIDAZOLE COMPOUNDS WITH ANTI-TUBERCULOSIS EFFECT

摘要

The invention relates to a process for obtaining a class of anthracene-imidazole compounds with anti-tuberculosis effect. According to the invention, the process consists in the N-alkylation of the nitrogen N1 from the imidazole, and benzimidazole, respectively, with 9-chloromethyl-anthracene, to result in the intermediates 1-(anthracenyl-9-methylene)-1H-imidazole and 1-(anthracenyl-9-methylene)-1H-benzimidazole, followed by the reaction of quaternization with Z-substituted Ω -bromo-acetophenones of the imidazole/benzimidazole nitrogen N3, to result in the 1-(anthracenyl-9-methylene)-3-(2-(4-Z-phenyl)-2-oxoethyl)-1H-imidazol-3-ium bromide and the 1-(anthracenyl-9-methylene)-3-(2-(4-Z-phenyl)-2-oxoethyl)-1H-benzimidazol-3-ium bromide, respectively.