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METHOD FOR DETERMINING THE SUSCEPTIBILITY OF A PATIENT SUFFERING FROM PROLIFERATIVE DISEASE TO TREATMENT USING AN AGENT WHICH TARGETS A COMPONENT OF THE PD1/PD-L1 PATHWAY
METHOD FOR DETERMINING THE SUSCEPTIBILITY OF A PATIENT SUFFERING FROM PROLIFERATIVE DISEASE TO TREATMENT USING AN AGENT WHICH TARGETS A COMPONENT OF THE PD1/PD-L1 PATHWAY
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机译:一种以PD1 / PD-L1通路为靶标的代理商确定从增生性疾病到治疗的患者敏感性的方法
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摘要
A method for determining the susceptibility of a patient suffering from proliferative disease to treatment using an agent which targets a component of the PD1/PD-L1 pathway, said method comprising determining in a tumour sample from said patient at least three biomarkers selected from list including those directly related to the PD-1/PD-L1 pathway as well as other oncogenic biomarkers and the tumour mutational burden, and relating the presence of more than one of said biomarkers as an indicator susceptibility to said agent. Methods for making the determinations and algorithms for dealing with the results are also described and claimed.
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