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Method for prognosis of survival time of a patient suffering from solid cancer

机译:实体瘤患者生存时间的预后方法

摘要

An in vitro method for the prognosis of survival of a patient suffering from solid cancer, comprising the following steps: a) to quantify, in a sample of tumor tissue from said patient, the cell density of CD8 + cells, b) to quantify, in a tumor-induced lymphoid structure of said patient, the cell density of DC-LAMP + dendritic cells, c) comparing the cell density values obtained in step a) and b) with predetermined reference values for each type of cells in each location, and d) providing a favorable prognosis of survival time for said patient when the cell density of CD8 + cells and DC-LAMP + dendritic cells is higher than said predetermined reference values, providing a poor prognosis of survival time for said patient when the density CD8 + cell and DC-LAMP + dendritic cells are below these predetermined reference values, or provide an intermediate prognosis of survival time for said patient when the cell density of one marker is greater than said predetermined reference value and the cell density of the other marker is less than said predetermined reference value, wherein the method is used in combined with TNM staging classification.
机译:一种用于对实体癌患者的生存进行预后的体外方法,包括以下步骤:a)在所述患者的肿瘤组织样品中量化CD8 +细胞的细胞密度,b)量化,在所述患者的肿瘤诱导的淋巴样结构中,DC-LAMP +树突状细胞的细胞密度,c)将步骤a)和b)中获得的细胞密度值与每个位置的每种细胞的预定参考值进行比较, d)当CD8 +细胞和DC-LAMP +树突状细胞的细胞密度高于所述预定参考值时,为所述患者提供有利的生存时间预后,当密度CD8 +时,为所述患者提供较差的生存时间预后+细胞和DC-LAMP +树突状细胞低于这些预定参考值,或者当一种标记物的细胞密度大于所述预定参考值和t时,为所述患者提供中间生存期预后另一个标记的细胞密度小于所述预定参考值,其中该方法与TNM分期分类结合使用。

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