Combination therapy comprising an inflammatory immunocytokine and a chimeric antigen receptor (CAR) T cell

摘要

Combination comprising at least a) a fusion protein comprising a1) a binding protein that specifically recognizes a cancer-related antigen and a2) an inflammatory cytokine, and b) a chimeric antigen receptor (CAR) T cell that recognizes a cancer-related antigen, wherein the binding protein comprises at least one of the group selected from - antibody, - modified antibody format, - antibody fragment or derivative that retains target-binding properties - binding protein based on antibodies, - oligopeptide binder and / or - an antibody mimetic.