Enhanced Recombinant Human Follicle Stimulating Hormone

摘要

A recombinant FSH preparation, wherein the recombinant FSH in the preparation has a glycosylation pattern comprising the following characteristics: (i) a relative amount of bisectant N-acetylglucosmin bearing glycans (bisGlcNAc) of at least 20% of the amount total glycans bound to FSH in the preparation; and (ii) a relative amount of 2,6-coupled sialic acid of at least 30% of the total amount of sialic acids; and (iii) a relative amount of glycans bearing a sulfate group of at least 3% of the total amount of glycans bound to FSH in the preparation.