Biomarker to predict the primary function failure of a liver graft

摘要

A procedure for predicting the onset of primary non-function of a liver graft, comprising: - collecting a perfusate from a donor liver, and - determining the relative abundance of the biantennial asialo-agalacto-fucosylated N-glycan oligosaccharide ( NGA2F) and / or the agalactosylated biantenary bisecting bisecting α-1,6-fucosylated N-glycan oligosaccharide (NGA2FB) and / or the monogalactosylated biantennial nucleus-α-1,6-fucosylated N-glycan oligosaccharide (NG1A2F) in said perfusate, where a significantly higher amount of NGA2F and / or NGA2FB and / or NG1A2F compared to the amount respectively of NGA2F and / or NGA2FB and / or NG1A2F in a perfusate collected from a control liver, is predictive of the appearance of lack of primary function of the liver graft.