Anti-KIR antibodies for the treatment of inflammatory disorders

摘要

An antibody or antigen-binding fragment thereof that binds to KIR2DL1, KIR2DL2 and / or KIR2DL3 and enhances the cytotoxic activity of natural killer (NK) lymphocytes, blocking or neutralizing the inhibition of NK cells mediated by a KIR2DL1 polypeptide , KIR2DL2 and / or KIR2DL3 expressed in NK cells, for use in the treatment of an autoimmune disorder or an inflammatory disorder, wherein the antibody or antigen-binding fragment thereof reduces the number of T lymphocytes involved in the mediation of inflammatory disorder or immune disorder.